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By reliably monitoring the impact of changes in temperature, pH and other aspects of the chemical environment the SCISSOR system allows formulators to replace in vivo tests of questionable value with in vitro strategies with stronger predictive power

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For example, in adipocyte insulin resistance, insulin-regulated protein dephosphorylation was preferentially impaired compared with phosphorylation [34], suggesting that there is dysregulation of insulin-activated protein phosphatases and/or insulin-deactivated kinases in insulin resistance