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In addition to weight loss, Wegovy is approved to lower the risk of serious heart problems like heart attacks and stroke in obese or overweight adults with heart disease and is also approved to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) who have moderate-to-advanced liver fibrosis (scarring)

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In osteoarthritis (OA), SHMT2 expression is elevated in chondrocytes, and miR-370 affects the pathological process of osteoarthritis by altering 1C metabolism and DNA methylation through negative regulation of SHMT2 expression [150]