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Dietary sources include wheat bran (1,339 mg/100 g), spinach (600645 mg/100 g), beets (114297 mg/100 g), shrimp (219 mg/100 g), and whole wheat bread (20 mg/100 g)

In hypercholesterolemic patients (n = 8, mean age 51.5) with slight luminal irregularities of the left anterior descending coronary artery (LAD), ACh-induced reduction in coronary blood flow, an indication of endothelial dysfunction, is improved by intracoronary injection of L-arginine (Drexler et al., 1991)

Critically, these lipid peroxidation products, particularly 4-HNE and 4-oxo-2-nonenal (ONE), enhance the stability and yield of -syn oligomers, promoting their pathological deposition