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3.1 Therapeutic potential of probiotics in anxiety and depression and related mechanisms Depression and anxiety are psychiatric disorders associated with genetic, environmental factors, endocrine and neural dysregulation, inflammation, stress, epigenetic mechanisms and, more recently, evidence reinforces the role of the GM (45, 46)

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Its N-terminal mART domain connects via a hinge and extensive interface to two tandem C-terminal -trident subdomains (D2 + D3) ( 2.3 Lipid-associated membrane proteins LAMPs serve as a key interface for pathogenhost interactions and function as potent proinflammatory molecules