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This study was approved by the Ethics Committee for Animal Experimentation of the University of Barcelona (CEEA-UB

Mechanistic Research Characteristics Modulation of intracellular signalling pathways in controlled in-vitro systems Influence on growth factor sensitivity and molecular activation cascades Regulation of gene expression patterns in peptide-based research models Interaction with mitochondrial ATP dynamics and metabolic pathways Support of enzymatic response analysis and pathway-driven research designs Primary Research Applications Synergistic Peptide Interaction Studies: Evaluating interaction effects and signal modulation between multiple peptide pathways

30 The latitudinal location of each study was used as a surrogate measure of population UV exposure in the present study

Testing for the presence of the HLA-B58:01 allele was positive in both cases