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Research suggests this is because stress triggers changes in the central dopamine system, which could theoretically contribute to the disease (Dugger and Dickson 2017

These include: physical aches and pains that can range from uncomfortable to severe abnormal sensations, such as the feeling that bugs are crawling on the skin muscle spasms hyperventilation sweating weight loss anorexia anxiety attacks trouble concentrating hypersensitivity nausea vomiting insomnia panic attacks grand mal seizures detachment from reality depression hallucinations or delusions Along with these symptoms, the person may experience severe cravings for the drug or other drugs to sedate them

J., Deacon, C

In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity