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Animal studies have shown that 95% hyperoxia substantially enhanced cellular ROS generation, increased apoptosis, induced TRX-1 and TRXR-1 expression while the TRXR-1 activity was reduced

Ok, Y.S

Mol Cell Biochem 77(1):310

doi: 10.3389/fimmu.2025.1576141 Received 13 February 2025 Accepted 03 April 2025 Published 22 April 2025 Volume 16 - 2025 Edited by Teresa Zelante, University of Perugia, Italy Reviewed by Hideki Yoshimatsu, Osaka Dental University, Japan Felipe Melo-Gonzalez, Andres Bello University, Chile Updates Copyright 2025 Ye, Li, Wang and Yang