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The joint that is affected may also appear to be red and swollen, but this is often indicative of a more serious condition that should be examined by a joint specialist promptly to ensure that there is no infection that is present

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care

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It plays an integral role in the body's energy production process