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The first is that the science is interesting but incomplete

doi: 10.1016/j.jacc.2017.05.034 74

In particular, how polymer exposure perturbs cellular metabolism and promotes the transition from inflammation to fibrosis is a critical, unanswered question

The human glutathione S-transferase, possess both enzymatic and non-enzymatic functions and are involved in many important cellular processes, such as, phase II metabolism, stress response, cell proliferation, apoptosis, oncogenesis, tumor progression and drug resistance