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doi: 10.1016/j.neubiorev.2015.04.008 47 LawJKCButlerLTHamillMM

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(131) analyzed the network pharmacology system and found that quercetin may further improve the pathophysiological changes of HF by regulating the AKT1-eNOS-MMP9 pathway to resist apoptosis

In this review, we summarize both classical mechanisms and recent discoveries, with a focus on novel perspectives such as cellular heterogeneity, the roles of metabolites [Figure 1], and intercellular communication [Figure 2]