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The possible explanations for the lack of effect of pregabalin on painful DPN include the use of low-dose pregabalin, a placebo response in people with painful DPN, or a carryover effect

This can result in poorer support and stabilization of the cervical spine, making it more susceptible to injuries that can cause radiculopathy

The peroxisome is responsible for the -oxidation of long chain fatty acids and the synthesis of ether-phospholipids such as plasmalogens, bile acids and the PUFA docosahexaenoic acid (DHA) (Van Veldhoven, 2010)