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Sirtuins are a family of NAD + -dependent deacylases that have been shown to regulate a myriad of biological functions, ranging from cell growth to lifespan extension, including oxidative stress, DNA damage, glycolysis, gluconeogenesis, and lipogenesis [1316]

Although statistical significance was not observed in the Liverpool replication cohort because of its small sample size, the direction of effect was consistent with the primary analysis

Overall, these findings demonstrate that Cagrilintide exerts potent, RAMP-dependent effects on food intake, body weight, and neuronal activation

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