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The local production of IGF-1 is controlled primarily by GH and other hormones (e.g., parathyroid and thyroid hormones) (Bikle et al., 2009)

Febbraro F, Andersen KJ, Sanchez-Guajardo V, Tentillier N, Romero-Ramos M

Symptoms that HRT was managing typically return gradually after stopping usually within 26 months depending on how long you were on the protocol and your baseline hormone levels