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Egypt J Pediatr Allergy Immunol

The activation of the DAG-PKC pathway increases ROS production via NADPH oxidase, reinforcing OS, while simultaneously disrupting mitochondrial electron transport, uncoupling endothelial nitric oxide synthetase and influencing transcription factors, such as NF-B, which promotes pro-inflammatory signaling (38)

Anderson GJ, Frazer DM (2017) Current understanding of iron homeostasis