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Samples were then evaporated to dryness in Speed vac and resuspended in 500 l Buffer A (95% H 2 O, 5% CH 3 CN, 0.1% FA) with sonication and loaded on HPLC for offline high pH fractionation following conditions adapted from previous work 57

Clinically, the broad therapeutic potential of curcumin has been explored in conditions ranging from metabolic and inflammatory disorders (e.g., arthritis, diabetes, inflammatory bowel disease) to cancer and neurodegenerative diseases (Sohn et al., 2102

ERK 1/2 and protein kinase C (PKC) were identified as key regulators of Nrf2 phosphorylation induced by baicalein or baicalin

doi: 10.1021/acs.nanolett.9b03817