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Furthermore, this benefit largely persisted at 6-, 9- and 12-month, but disappeared at 24 months post-randomization [125]

In some rare cases, such as when a tophus is infected or when its location is causing major disability, surgical removal may be considered

Areas That Respond Best to Treatment Double chin and jawline - one of the most popular treatment zones Love handles and flanks - those stubborn side bulges Lower abdomen - the area below the belly button Inner and outer thighs - where fat tends to cluster Bra bulge - the back area where bras create rolls The reason some people see better results than others comes down to a few factors

[10] Long-term use of proton pump inhibitors (PPIs) and H2-receptor antagonists reduces gastric acid, potentially impairing the release of B12 from dietary proteins