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In briefing documents submitted to the FDA's Pharmacy Compounding Advisory Committee, some experts warned that the peptides are "extremely sensitive" to formulation and environmental conditions and lack evidence that they treat the conditions claimed

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(Some women apply retinols on alternating nights or twice weekly to avoid the skin irritation that can come with daily useor skip it altogether and just use GHK-Cu peptides topically.) If you have sensitive skin thats irritated by either retinol or vitamin C, then using a GHK-Cu peptide can be an effective and non-irritating option to promote collagen synthesis in the skin