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B 1 map was acquired using the dual-echo FLASH sequence

Neurology 32, 567570

Through an integrative approach combining coarse-grained molecular dynamics simulations, free energy calculations, in vitro lipid-binding assays, and subcellular analyses in embryonic mouse brains, we show that the M105I mutation conceals a critical hydrophobic loop in the N-terminal region and reduces its affinity for plasma membranederived lipids