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Aging Cell 12 , 10621072 (2013)

RhoA/ROCK-2 pathway inhibition and tight junction protein upregulation by catalpol suppresses lipopolysaccaride-induced disruption of blood-brain barrier permeability

Clinical behaviors frequently associated with copper overload autism Sudden emotional outbursts without clear external trigger High irritability or agitation during noise, transitions, or crowds Panic or fear-based behavior Sensory oversensitivity (especially auditory) Hyperactivity alternating with emotional collapse Cyclical mood swings Poor tolerance to stimulants or SSRIs These patterns represent a neurochemical imbalance not behavioral stubbornness or lack of discipline

Ergogenic attributes of young and mature coconut ( Cocos nucifera L.) water based on physical properties, sugars, and electrolytes contents