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Naturally, the human body continuously produces a small amount of ketone bodies, which can then be used to produce energy (98)

[DOI] [PubMed] [Google Scholar] 71.Pylypchuk G, Oreopoulos DG, Wilson DR, et al

Since disulfiram was previously shown to have a sub-micromolar IC 50 [37] (see also dose response data for disulfiram in Additional file 1: Figure S7), the goal was to identify superadditive drug combinations that involve disulfiram

It could be responsible for maintaining homeostasis between DNA damage, senescence, and apoptosis under oxidative stress ( SIRT1 is redistributed at the chromatin level, causing deregulation at the transcription level and DNA damage ( SIRT-1 mRNA expression and induces apoptosis (Tinkov et al., 2021)