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First, a random-effects pairwise meta-analysis with a Bayesian framework was performed to estimate direct estimates (Reference Ades, Sculpher and Sutton17,Reference Lumley18)

It is a subtle change that happens at the cellular level rather than a surface-level transformation

When collagen breaks down faster than the body can replace it, we may notice the first signs of fine lines, less firm skin, and a change in skin texture