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Recommended medications 1 Administer medications as outlined below to reduce the risk of CRS Recommended pre- and post-administration medications prior to EPKINLY administration CYCLE 1 Administered prior to each weekly administration of EPKINLY to all patients Dexamethasone or Prednisolone or equivalent 15 mg oral or IV (dexamethasone), 100 mg oral or IV (prednisolone), or equivalent And for 3 consecutive days following each weekly administration of EPKINLY in cycle 1 Diphenhydramine or equivalent 50 mg oral or IV, or equivalent Acetaminophen 650 mg to 1000 mg oral CYCLES 2+ Administered prior to next administration of EPKINLY to patients who experienced grade 2 or 3 CRS with previous dose, until EPKINLY is given without subsequent CRS of grade 2 or higher Dexamethasone or Prednisolone or equivalent 15 mg oral or IV (dexamethasone), 100 mg oral or IV (prednisolone), or equivalent Administer prior to the next administration of EPKINLY and for 3 consecutive days following each weekly administration of EPKINLY Diphenhydramine or equivalent N/A Dexamethasone is the preferred corticosteroid when available

The IV route delivers glutathione directly into the bloodstream, bypassing enzymatic degradation in the gastrointestinal tract