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If mutational disruption of a gene negatively affects cell proliferation/viability, the levels of IRFP670-positive cells decrease, as exemplified by knockout of the essential gene encoding the 60 S ribosomal protein L17 ( RPL17 )

Additionally, we calculated the area under ROC curves of the 3-year (AUC = 0.680) and 5-year (AUC = 0.674) survival prediction to test the specificity and sensitivity of the nomogram model