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Typically, you can start to feel the positive effects of the IM shot, between 24 - 72 hours post injection, dependent of current levels of B12 in the body

Ive taken this for 6 weeks so far and it seems to be helping Gives me a lot of energy

A 2024 Diabetes, Obesity and Metabolism study on a small-molecule NNMT inhibitor found it dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity, and suppressed hyperinsulinaemia in obese mice (PMID 39161060) [6]

So in conjunction with a rapid medically supervised weight loss program or a body sculpting treatment (like CoolSculpting, Physiq, SculpSure) that breaks down fat cells, they do indeed help the liver process those fat cells out of the body