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doi: 10.1371/journal.pone.0054087 105 MajbourN

However, it's important to note that having only methylfolate in your prenatal supplement won't be enough if you're dealing with methylation blockages

RASFs, RA synovial fibroblasts

In the context of Fabry Disease, Gb3 accumulation also leads to the activation of toll like receptors (TLRs) particularly TLR4 (1012), which in turn stimulates the production of pro-inflammatory cytokines and chemokines, further amplifying the inflammatory response