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Description

The historically important question, which has been the subject of frequent discussions, is whether oxidative stress is the primary cause or secondary consequence of the disease

Glycine and mitochondrial function and oxidative phosphorylation The glycine cleavage system (GCS) is an important metabolic pathway in mitochondria

Located within the mitochondrial matrix, the TCA cycle produces the reduced cofactors NADH and FADH_2, which serve as the primary electron donors for the electron transport chain (ETC)

Funding This work was supported by the National Natural Science Foundation of China (82130109, U2202214, U21A20410), the Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Medicine & Pharmaceutical Science (2202401) and CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1020)