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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Hakim A

BDNF/TrkB signaling is involved in the occurrence, development, growth and metastasis of multiple cancers including brain, breast, urological, and gastrointestinal cancers (Guzel et al., 2021)

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Once expressed, the antibodies, individual mutated immunoglobulin chains, mutated antibody fragments, and other immunoglobulin polypeptides of the invention can be purified according to standard procedures of the art, including ammonium sulfate precipitation, fraction column chromatography, gel electrophoresis and the like (see, generally