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Tumour heterogeneity and the ability of tumour cells to rapidly mutate and develop evasion strategies makes the development of non-invasive imaging capabilities to interrogate these hallmarks as biomarkers and monitor them longitudinally and quantitatively particularly important

The inefficient recycling of Se in BAT for the synthesis of selenoproteins, particularly GPX1 and GPX4 which are involved in adaptive thermogenesis, may potentially lead to increased oxidative stress within this tissue, yet is insufficient to curb heat production

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