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Asthana P, Zhang G, Sheikh KA, Him Eddie Ma C (2021) Heat shock protein is a key therapeutic target for nerve repair in autoimmune peripheral neuropathy and severe peripheral nerve injury

They are also beneficial for individuals with poor dietary intake of B12 (including vegetarians and vegans), older adults with reduced absorption, patients with digestive conditions like Crohns disease or celiac disease, and those managing conditions like anemia, sciatica, or peripheral neuropathy

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Despite this miniature size it has an extremely broad effect at the cellular level, it modulates the expression of more than 4,000 human genes (Pickart & Margolina 2012)