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A polymeric nanoparticle formulation of curcumin (NanoCurc) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

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To determine whether the haem-degrading activity of HMOX2 is essential for maintaining mitochondrial iron levels, we generated stable expression cells in which HMOX2 WT or HMOX2 HW/GW mutants were re-expressed in HMOX2 KO cells, and confirmed their subcellular localization to the ER (Extended Data Fig

The psychological mechanisms involved, including cognitive distortions and maladaptive coping strategies, further complicate the picture, making it essential to consider both the biological and psychological perspectives in this context