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At the same time, hypoglycemia upregulates B56, the PP2A regulatory subunit, resulting in the formation of a PP2A-B56 active complex with a high affinity toward GSK3 to specifically activate the PP2A-GSK3 axis, leading to a decline in the pro-survival protein MCL-1, thereby interfering with glycolysis in hepatocellular carcinoma cells (81)

As is known, vascular endothelial levels are closely correlated with the concept of angiogenesis (Callahan et al

Pemetrexed can cause bone marrow function to decrease, which may lead to a reduction in blood cells

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