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The ideal pharmacological agent for UF should be effective and affordable, with a short treatment duration and minimal adverse effects

Metformin, as an AMPK activator, inhibits the AMPK-mTOR-STAT3 axis, reduces mtDNA mutations and ROS generation in lupus models, and enhances mitophagy

doi: 10.1128/JB.00011-07 276 TalaatA

We found that pharmacological MT1 and MT2 agonism failed to replicate the effects of melatonin in suppressing IL-5 production ( Figures 3B, D ) or IL-13 production ( Figures 3C, E )