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In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Disclosure of interest: Orhun Utku Aydin: Nothing to disclose, Jana Rieger: Nothing to disclose, Dimitrios Rallios: Nothing to disclose, Satoru Tanioka: Nothing to disclose, Charles Majoie: Nothing to disclose, Wim van Zwam: Nothing to disclose, Aad van der Lugt: Nothing to disclose, Adam Hilbert: Nothing to disclose, Dietmar Frey: Nothing to disclose Table 1

Regenerative Medicine & Non Surgical Orthopedic Care Dr Thomas Agesen and Dr Jay Bowen 299 Cherry Hill Road, Suite 105, Parsippany, NJ 07054 New Jersey Regenerative Institute is now at the following address: 299 Cherry Hill Road, STE 105, Parsippany, NJ 07054 * *Please note that the entrance to our new office, Suite 105, is accessed from the parking lot on the left side of the building