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It is well-known that there is an interaction between the immune system and the microbiome, involving hormone receptors, various immune mediators, stem cells, different subpopulations of leukocytes, plasma cells, and antibodies such as IgG, IgM, and IgA, along with interleukins and inflammatory proteins

Researchers actively use it to study receptor interactions and molecular signalling pathways in controlled laboratory environments

Mol Cell Biol 25(15):64156426

Given the increasingly elucidated prominence of gut-related factors in osteoblasts/osteoclasts and bone formation/metabolism/maintenance, focusing on intestinal microecology and then targeting the distal bone tissue via the gutbone axis have been recognized as a feasible intervention strategy