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Acetaldehyde, present in premalignant as well as malignant lesions, induces DNA damage by forming bulky adducts and inhibiting DNA repair mechanisms like O6-methylguanine transferase (MGMT) [184, 185]

Fernandez-Barrena: Nothing to Disclose, Laura Alvarez: Nothing to Disclose, Colm O'Rourke: Nothing to Disclose, Pui-Yuen Lee-Law: Nothing to Disclose, Kyle Davies: Nothing to Disclose, Andreea Gradinaru: Nothing to Disclose, Raul Jimenez-Aguero: Nothing to Disclose, Adelaida La Casta: Nothing to Disclose, Ioana Riao: Nothing to Disclose, Rocio Macias: Nothing to Disclose, Jose J G Marin: Nothing to Disclose, Maria L Martinez-Chantar: Nothing to Disclose, Matias A Avila: Nothing to Disclose, Patricia Aspichueta: Nothing to Disclose, Jesper B Andersen: Nothing to Disclose, Luke Boulter: Nothing to Disclose, Luis Bujanda: Nothing to Disclose, Pedro M Rodrigues: Nothing to Disclose, Maria J Perugorria: Nothing to Disclose, Jesus M Banales: Nothing to Disclose 1936 THE INVOLVEMENT OF MICRORNA-1297 IN LENVATINIB RESISTANCE IN HEPATOCELLULAR CARCINOMA CELLS Takayuki Kogure 1 Mari Satoh 1 Takehito Ito 1 Kennichi Satoh 1 , 1 Tohoku Medical and Pharmaceutical University Background: Lenvatinib for treating hepatocellular carcinoma (HCC) has a superior response rate, although its overall survival is non-inferior to sorafenib, suggesting tumor cells may acquire resistance during therapy

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10.1016/j.lfs.2008.11.003 [DOI] [PubMed] [Google Scholar] Chen W., Zhou Y., Kang J., Li Q., Feng X