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Results Integrated single-cell and single-nucleus transcriptomic datasets from mouse demyelination models and MS patient samples To compare the effects of LPC- and CPZ-induced demyelination on different WM cells, we performed snRNA-seq of the adult mouse corpus callosum, and integrated our data with two additional published scRNA-seq studies of the corpus callosum following LPC- or CPZ-induced demyelination 8,9

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Myocardial oxygen consumption was calculated according to Neely (Neely et al., 1967) considering coronary flow and heart dry weight, which averaged 0.212 g in adults and 0.237 g in old animals