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Microglia priming with aging and stress

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11,12 Metabolic reprogramming supports the ability of the liver to adapt to its metabolic landscape in response to various types of damage, ensuring that sufficient resources and energy are available for cell proliferation and repair

Transition metals with two contiguous oxidation states, typically Fe and Cu, but also Co and Ni, are able to catalytically convert endogenous, naturally produced hydrogen peroxide into the hydroxyl radical through radical-chain mechanisms such as that long known as the Fenton reaction [12] (Scheme 2)