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In that sense, HRT appears to potentiate the effect of the most common anti-parkinsonian drug, levodopa, reducing its response threshold and enhancing its sensitivity (Gomez-Mancilla and Bedard, 1992

Thus supplementation is often required to maintain healthy levels.

Studies have demonstrated that PHGDH overexpression enables breast cancer cells to redirect more glutamine into the tricarboxylic acid cycle via the SSP, thereby supporting rapid cell proliferation (68, 69)