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In endothelial tissue, exosomes act as messengers, transporting these bioactive molecules to neighboring or distant cells, immune cells, or smooth muscle cells, thereby influencing cellular functions

119 In 2011, a groundbreaking study revealed that transcription factor EB (TFEB) broadly regulates genes involved in autophagy and lysosome biogenesis at the transcriptional level, marking a pivotal shift in the understanding of the control of autophagy in the nucleus

Samples for measurements with GSH were also supplemented with 1 U GR and 100 M NADPH to remove traces of GSSG and to maintain a highly reducing redox state