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226-228 A trial in which 36 subjects with fibromyalgia received placebo and increasing doses of melatonin (3 mg, 6 mg, 9 mg, 12 mg, and 15 mg nightly) during alternating 10-day cycles found 9 mg, 12 mg, and 15 mg of melatonin per day decreased scores on the Fibromyalgia Impact Questionnaire, number of tender points, and urinary cortisol levels

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You need to inform your doctor about the following side effects as soon as possible : Allergic reactions like skin rash, itching, hives, face, lips, or tongue swell (it can be avoided by a skin test before the injection) Fluid Retention and swelling in various parts of the body Breathing problems Breast enlargement Enlargement of penis and testes Ovarian hyperstimulation syndrome (OHSS), in which the ovaries become swollen and painful