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Human leukocyte antigen alleles encode histocompatibility glycoproteins that enable the initiation of a specific immune response through the presentation of antigens to T cells and have been identified as risk factors for other skin diseases such as psoriasis [34]

EMR exposure may trigger oxidative stress by elevating free radical levels and impairing antioxidant enzymes like GSH, GPx, SOD, and CAT, potentially causing lipid peroxidation, protein oxidation, and DNA damage