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Refining the use of adjuvant oxaliplatin in clinical stage II or III rectal adenocarcinoma

To address organelle-specific pH and redox environments, turn-on zinc fluorescent probes (ZnDA-2H and ZnDA-3H) with low pH sensitivity and high affinity were developed and targeted to the cytosol, nucleus, ER and mitochondria using HaloTag technology, enabling the precise quantification of labile zinc distribution 189