These include quinic acid, danshensu, yunnaneic acid E, feruloylquinic acid, hydroxyjasmonic acid-O-hexoside, apigenin di-C-glucoside, eriodictyol-O-hexoside, quercetin glucuronide, quercetin-O-hexoside, salvianolic acid C derivative, luteolin-7-O-glucoside, luteolin-O-diglucoside, rosmarinic acid hexoside, rosmarinic acid derivatives, salvianolic acids A, B, and F derivatives, K, isoscutellarein-O-glucuronide, luteolin acetyl dipentoside, methyl rosmarinate, and caffeoyl rosmarinic acid
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However, low and medium doses led to the upregulation of Treg-associated genes and an increase in Foxp3 + cells in gut tissues, suggesting that low-dose immunotherapy promotes local regulatory T cell induction and regulatory cytokine upregulation
This review comprehensively discusses the sources and mechanisms of ROS generation, the associated pathophysiology of diseases, and the role of both endogenous and exogenous antioxidants in mitigating oxidative stress