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For example, the families Bacteroidaceae, Enterococcaceae, and Lactobacillaceae are more common in the intestinal lumen, while the families Lachnospiraceae, Ruminococcaceae are more common in the mucosa ( In general, commensal microorganisms participate in host digestion, biosynthesis of vitamins, production of short-chain fatty acids (SCFAs) and bacteriocins, development of the hosts immune system, and functioning of the gut-brain axis

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Endogenous DSIP has been detected in various brain regions, plasma, and peripheral tissues, though its concentrations are very low and its physiological fluctuations are not well-characterized

Graves, J