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The abnormal activation of these channels leads to the influx of Ca 2+ into the cell, which plays a critical role in the imbalance of the action potential and finally helps in the triggering and propagation of seizure

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The presence of inflammation in the lungs of patients with COPD is intimately linked to oxidative stress [8, 9], which is an imbalance between oxidant production and antioxidant defences in favour of oxidants