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Mechanistic uncertainty: In some other medications with well-defined mechanisms of action, the exact signaling pathways downstream of NAD + that mediate NMNs benefits are not fully understood, making therapeutic outcomes difficult to predict and control

However, the researchers the trial was marked as completed, but in 2016 they cancelled submission of the results never published the results This is a red flag: we dont know if an issue or toxicity was discovered, or if it was simply a business decision

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