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e , The potential inhibitory mechanism of desipramine on NET

Mani maran RR, Sivakumar R, Ravisankar B, et al

One is an oxidative pathway which uses L-arginine as a substrate and produces NO and citrulline while the other is a reductive pathway to produce NO from nitrate and nitrite as substrates, all of which exhibit enhanced vasoactive signaling in hypoxia and stress