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In ferroptosis, GSH functions as a cofactor for GPX4 activation to mitigate lipid peroxidation and ROS accumulation, whereas it serves as a copper chaperone to inhibit lipoylated protein aggregation in the TCA cycle in cuproptosis ( GSH, a common biomarker of oxidative stress, may act as the intersection of ferroptosis and cuproptosis during periodontitis ( 3+

Common side effects include local reactions at the injection site, hearing and vision impairment, and, less commonly, lung and kidney damage

As a result, inhibiting PHGDH, via RNA interference or pharmacological approaches, is able to hinder the proliferation of cancer cells [14, 73, 74]