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The recurring interplay of oxidative stress, inflammatory activation, and disrupted cellular signalling provides a unifying mechanistic framework linking renal, musculoskeletal, cutaneous, immunological, respiratory, gastrointestinal, and reproductive dysfunctions to those already described in cardiovascular, hepatic, and gonadal tissues (83)

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caudatus , despite being domesticated, exhibits higher genetic diversity than several of its wild relatives, due to continuous introgression (Stetter et al., 2015)

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