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Currently, most of the evidence is related rather than direct, and further exploration is needed in the future

In a post hoc analysis after 13 years of the study, a 13% increased risk of vitamin B12 deficiency per year of metformin use was reported (Aroda et al, 2016)

Phentermine-topiramate should be used cautiously in women of childbearing age because this drug combination may increase risk of oral cleft in children (Alfaris 2015)